Enterovirus 68 may cause polio-like paralysis in children.

A respiratory virus has sickened thousands of children across the US, and is rapidly spreading across the country. The CDC has analyzed samples, and found 40 incidences of enterovirus 68 (or D68) in Kansas City and Chicago. This infection may be life-threatening.

In addition to the states listed on the map, this illness has been reported in Michigan, New York, Virginia, South Carolina, and Alabama as of today.

Enterovirus 68 has aspects similar to rhinoviruses, which cause the common cold, and it spreads like the common cold, that is, from contaminated surfaces, person-to-person contact, and aerosols from sneezing.

Last February, it was reported that five cases of a polio-like illness had been observed in California children since late 2012. These patients also had severe respiratory symptoms.

Over the past 18 months, physicians in California have observed on rare occasions what may be a new disease, one in which patients, usually children, quickly and permanently lose muscle function in an arm or leg.

In some cases, patients have had infectious respiratory symptoms before the paralysis begins. The illness shares some features with polio, but it is not the same disease.

The cause of the disease is still unknown, but a strong possibility is that it is caused by a virus known as enterovirus-68, which was detected in two of five cases that Emmanuelle Waubant, MD, PhD, of UCSF Benioff Children’s Hospital, and Keith Van Haren, MD, of Stanford University’s Lucile Packard Children’s Hospital, will present in detail at the annual meeting of the American Academy of Neurology this spring.

An audio presentation by these neurologists can be found at this link. At 5:25 Dr. Van Haren states his belief that the polio-like paralysis was caused by enterovirus 68.

10 thoughts on “Enterovirus 68 may cause polio-like paralysis in children.

  1. Acute Neurologic Illness with Focal Limb Weakness of Unknown Etiology in Children

    The CDPHE, Children’s Hospital Colorado, and CDC are investigating nine cases of acute neurologic illness among pediatric patients. The cases were identified during August 9–September 17, 2014 among children aged 1–18 years (median age 10 years). Most of the children were from the Denver metropolitan area. All were hospitalized. Common features included acute focal limb weakness and specific findings on magnetic resonance imaging (MRI) of the spinal cord consisting of non-enhancing lesions largely restricted to the gray matter. In most cases, these lesions spanned more than one level of the spinal cord. Some also had acute cranial nerve dysfunction with correlating non-enhancing brainstem lesions on MRI. None of the children experienced altered mental status or seizures. None had any cortical, subcortical, basal ganglia, or thalamic lesions on MRI. Most children reported a febrile respiratory illness in the two weeks preceding development of neurologic symptoms. In most cases, cerebrospinal fluid (CSF) analyses demonstrated mild-moderate pleocytosis (increased cell count in the CSF) consistent with an inflammatory or infectious process. CSF testing to date has been negative for West Nile virus and enteroviruses, including poliovirus. Nasopharyngeal specimens were positive for rhinovirus/enterovirus in six out of eight patients that were tested. Of the six positive specimens, four were typed as EV-D68, and the other two are pending typing results. Testing of other specimens is still in process. Eight out of nine children have been confirmed to be up to date on polio vaccinations. Epidemiologic and laboratory investigations of these cases are ongoing.

    The United States is currently experiencing a nationwide outbreak of EV-D68 associated with severe respiratory disease. The possible linkage of this cluster of neurologic disease to this large EV-D68 outbreak is part of the current investigation. CDC is seeking information about other similar neurologic illnesses in all states, especially cases clustered in time and place. CDC has particular interest in characterizing the epidemiology and etiology of such cases.

    http://emergency.cdc.gov/han/han00370.asp

  2. Quote: “The B.C. Centre for Disease Control has confirmed another child tested positive for enterovirus D68 in the province, bringing the total number of cases to nine.”

    “There have been dozens of confirmed cases of EV-D68 in Canada, which usually causes only mild cold symptoms but in a small number of infected children can cause polio-like symptoms.”

    http://www.ctvnews.ca/health/b-c-confirms-9th-case-of-child-with-enterovirus-d68-1.2040316

    Elsewhere had heard that 46 states have confirmed or suspected this virus, yet a better source than “pharmapro” or “menageatroime” is lacking.

    Quote: “The CDC now confirms nearly 600 cases of Enterovirus d-68. Most victims are kids. The virus is in 43 states and Washington, DC. Vicente Arenas is at the children’s hospital of Philadelphia, where doctors are trying to understand the disease.”

    http://globalnews.ca/video/1602399/enterovirus-now-in-43-u-s-states

    • Title: “Enterovirus D68 linked to death of B.C. man with asthma
      1st confirmed death linked to the virus in Canada”

      “Number of cases doubles in B.C.

      The BCCDC said 36 cases of Enterovirus D68 have been confirmed in the province, double the number from last week.

      Skowronski said the confirmed cases have been found in every health authority in the province, and the patients age in range from less than one year old to more than 80.

      “However, consistent with elsewhere, 65 per cent of the cases are children under 10 years of age, and only about 15 to 20 per cent are adults 20 or more years of age,” she said.

      Skowronski added that two-thirds of the confirmed cases are male.

      7 deaths associated with D68 in U.S.

      Skowronski says the U.S. Centres for Disease Control is aware of seven deaths associated with D68 infections.

      Before the 2014 outbreak in North America, Skowronski says three deaths had been associated with the virus — two in the Philippines in 2008 and one in Japan in 2010.

      She adds the death in B.C. is the first health officials know of in Canada, as Enterovirus infections are not reportable in Canada or the U.S.

      “So it is possible that Enterovirus D68 has contributed, or associated with deaths previously, but those were not recognized,” says Skowronski.”

      http://www.cbc.ca/news/canada/british-columbia/enterovirus-d68-linked-to-death-of-b-c-man-with-asthma-1.2803626

      • The prevalence of ME is two-thirds female. Enterovirus 68 is two-thirds male.

        ME has something to do with the HPA axis and the pituitary. Women’s hormones are at a different ratio than men’s. I had a pituitary tumor, this certainly was a factor in getting ME.

  3. It seems eerily quiet in the news, save for a TV anchor’s family, a radio personality, and Tori Spelling, whom is suspected of having Enterovirus D68, and sadly some more passings.

    It seems all too quiet here on the Western Front. They said it was an illness only affecting children, and then i remembered you Rob, having had it (& possibly still), so i knew the media reporting, at minimum, on TPTB was pfaff {loosely akin to chaff/incl.Chaff(countermeasure)}, in my humble observation.

    Am assuming it has quadrupoled again here since last marked point in timespace (though have not yet confirmed or disproven).

    Quote: “”These clusters are still quite puzzling to me,” Pallansch said. “We have not found enterovirus D68 or any other pathogen in the children’s spinal fluid. We are expanding the search to more aggressively look at pathogens other than D68.”

    It’s a mystery that ultimately engulfed 51 children in 23 states between Aug. 1 and late October. A few more possible cases are being evaluated.

    Colorado’s cases — and another child treated here from a nearby state — remain the biggest single piece of the puzzle. About half the children in the cluster tested positive for EV-D68 in respiratory and other tissues samples. But half did not, instead testing positive for rhinoviruses.”

    http://www.denverpost.com/news/ci_26805066/investigators-look-beyond-enterovirus-cause-paralysis-51-kids

    Did the other half get a different mix of natural (et al) radionuclides &/or natural (including Cosmic(protons) & man(un)kind-made) photons via air, land and/or water-body?

    • The test for enterovirus 68 doesn’t always pick it up. But there can be other enteroviruses and other viruses that can cause muscle paralysis & ME.

      Really, the cause is toxins and radioactive toxins. The enterovirus just triggers the condition. If the body was toxin free, the immune system would clear the virus out. Radiation and enterovirus work together to screw up the immune system.

      • Thank you, and all those other gifted researchers referenced, for having opened my eyes up to these effects.
        Nobody, or few, else here locally seem to see a link, unless they are looking at a tidal pool. Even then, shamefully few are curious about tidal pools. I’m no longer calling this “North America”, but “N/A” in it’s stead. 🙁
        Our Continental Bird should be an Osterich.

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